A History of Organ Transplantation: Ancient Legends to Modern Practice

A History of Organ Transplantation: Ancient Legends to Modern Practice

by David Hamilton


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Foreword by Clyde Barker and Thomas E. Starzl

A History of Organ Transplantation is a comprehensive and ambitious exploration of transplant surgery—which, surprisingly, is one of the longest continuous medical endeavors in history. Moreover, no other medical enterprise has had so many multiple interactions with other fields, including biology, ethics, law, government, and technology. Exploring the medical, scientific, and surgical events that led to modern transplant techniques, Hamilton argues that progress in successful transplantation required a unique combination of multiple methods, bold surgical empiricism, and major immunological insights in order for surgeons to develop an understanding of the body’s most complex and mysterious mechanisms.  Surgical progress was nonlinear, sometimes reverting and sometimes significantly advancing through luck, serendipity, or helpful accidents of nature.
      The first book of its kind, A History of Organ Transplantation examines the evolution of surgical tissue replacement from classical times to the medieval period to the present day. This well-executed volume will be useful to undergraduates, graduate students, scholars, surgeons, and the general public. Both Western and non-Western experiences as well as folk practices are included. 

Product Details

ISBN-13: 9780822944133
Publisher: University of Pittsburgh Press
Publication date: 06/28/2012
Edition description: 1
Pages: 560
Product dimensions: 7.00(w) x 10.00(h) x 1.50(d)

About the Author

David Hamilton is a retired surgeon and honorary senior lecturer at the Medical School of St. Andrews University, where he teaches medical history. He is the author of two previous books, The Monkey Gland Affair and The Healers: A History of Medicine in Scotland.

Table of Contents

Foreword Clyde F. Barker Thomas E. Starzl vii

Acknowledgments xi

Introduction: Toward the Impossible xiii

1 Early Transplantation 1

2 The Eighteenth Century 31

3 The Reawakening 49

4 Clinical and Academic Transplantation in Paris 65

5 The Beginning of Organ Transplantation 88

6 The "Lost Era" of Transplantation Immunology 105

7 Anarchy in the 1920s 126

8 Progress in the 1930s 154

9 Understanding the Mechanism 173

10 Experimental Organ Transplantation 195

11 Transplantation Tolerance and Beyond 221

12 Hopes for Radiation Tolerance 254

13 The Emergence of Chemical Immunosuppression 269

14 Support from Hemodialysis and Immunology in the 1960s 296

15 Progress in the Mid-1960s 314

16 Brain Death and the "Year of the Heart" 340

17 The Plateau of the Early 1970s 359

18 The Arrival of Cyclosporine 380

19 Waiting for the Xenografts 413

Conclusion: Lessons from the History of Transplantation 423

Notes 431

Bibliographic Essay 527

Index 539

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