ISBN-10:
0202362647
ISBN-13:
9780202362649
Pub. Date:
09/09/2009
Publisher:
Transaction Publishers
Abnormal Hemoglobins in Human Populations / Edition 1

Abnormal Hemoglobins in Human Populations / Edition 1

by Frank. B. Livingstone, Jonathan MarksFrank. B. Livingstone
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Overview

Research on abnormal human hemoglobins (protein in blood that carries oxygen), has taught us about the inheritance, biochemistry, and distribution of these traits. This knowledge, coupled with mathematical research using computer models of population genetics, has enabled researchers to marry biological fact and genetic theory. This volume places medical understanding in an evolutionary framework. Using published data on the frequencies of abnormal hemoglobins in the world's populations, Livingston analyzes and interprets these frequencies in the light of world distribution of different forms of diseases such as malaria. He further develops the genetic theory of the evolutionary homeostasis. Livingston discusses the relation of abnormal hemoglobins to endemic malaria and, shows how natural selection pressures explain the known distribution of these traits. Where non-coinciding distributions arise, the book presents other genetic, anthropological, evolutionary, and epidemiological evidence to explain these discrepancies. This classic work remains a useful sourcebook for professors and graduate students of anthropology, genetics, epidemiology, and hematology.

Product Details

ISBN-13: 9780202362649
Publisher: Transaction Publishers
Publication date: 09/09/2009
Pages: 490
Product dimensions: 6.00(w) x 9.00(h) x 1.10(d)

About the Author

Frank B. Livingstone was professor emeritus of biological anthropology at the University of Michigan. He recieved the Martin Luther King Award from the Southern Christian Leadership Conference for his groundbreaking research on sickle cell anemia and is the author of Data on the Abnormal Hemoglobin's and Glucose-Six-Phosphate Deficiency in Human Populations.

Jonathan Marks is a professor of anthropology, at the University of North Carolina, Charlotte. He earned his M.S. in genetics, and M.A. and Ph.D. in anthropology at the University of Arizona, and has conducted postdoctoral research in genetics at the University of California at Davis. Mark's work on "molecular anthropology" has been widely published in professional journals.

Table of Contents

INTRODUCTION TO THE ALDINE TRANSACTION EDITION
PREFACE
LIST OF ILLUSTRATIONS
LIST OF TABLES

I INTRODUCTION
II THE ABNORMAL HEMOGLOBINS AND THALASSEMIA
III THE GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY
IV THE POPULATION GENETICS OF THE RED CELL DEFECTS
V SELECTION FOR THE RED CELL DEFECTS
VI EASTERN ASIA AND THE PACIFIC
VII INDIA, TIBET, PAKISTAN, AND CEYLON
VIII THE MIDDLE EAST AND EUROPE
IX NORTH AND WEST AFRICA
X CENTRAL AND EAST AFRICA
XI THE AMERICAS
XII CONCLUSIONS

BIBLIOGRAPHY
APPENDIX: THE FREQUENCIES OF THE RED CELL DEFECTS IN HUMAN POPULATIONS
INDEX TO APPENDIX

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