Pub. Date:
Elsevier Science
Basic aspects of Catechol-O-methyltransferase and the clinical applications of its inhibitors

Basic aspects of Catechol-O-methyltransferase and the clinical applications of its inhibitors

by Elsevier ScienceElsevier Science
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Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson’s disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson’s disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use.

  • Up-to-date summary of biochemistry and pharmacology of COMT and its inhibitors
  • Preclinical models in COMT inhibitor devlopment
  • Transgenic COMT mice – latest information summarized
  • Chemistry of COMT inhibitors and their design with molecular modelling
  • COMT gene and its regulation and relation to dopamine related diseases
  • Role of cofactor SAM regulation in relation to homocysteine
  • Nonclinical and clinical safety of COMT inhibitors summarized
  • Future prospects of COMT inhibitors in Parkinson’s disease

Product Details

ISBN-13: 9780123813268
Publisher: Elsevier Science
Publication date: 12/16/2010
Series: International Review of Neurobiology Series , #95
Pages: 336
Product dimensions: 6.20(w) x 9.00(h) x 0.90(d)

Table of Contents

  1. Introductory remarks: Catechol-O-methyltransferase inhibition: an innovative approach to enhance L-dopa therapy in Parkinson’s disease with dual enzyme inhibition
  2. Erkki Nissinen

  3. The catechol-O-methyltransferase gene, its regulation and polymorphisms
  4. Elizabeth M. Tunbridge

  5. Distribution and functions of catechol-O-methyltransferase proteins: do recent findings change the picture?
  6. Timo T. Myöhänen & Pekka T. Männistö

  7. Catechol-O-methyltransferase enzyme: Cofactor S-adenosyl-L-methionine and related mechanisms
  8. Thomas Müller

  9. Biochemistry and pharmacology of catechol-O-methyltrasferase inhibitors
  10. Erkki Nissinen and Pekka T. Männistö

  11. The Chemistry of Catechol-O-methyltransferase Inhibitors
  12. David A. Learmonth, László E. Kiss and Patrício Soares-da-Silva

  13. Toxicology and safety of COMT inhibitors
  14. Kristiina Haasio

  15. Catechol-O-methyltransferase inhibitors in preclinical models as adjuncts of the L-dopa treatment
  16. Concepció Marin, J.A. Obeso

  17. Problems with the present inhibitors and a relevance of new and improved COMT inhibitors in Parkinson’s disease
  18. Seppo Kaakkola

  19. Catechol-O-methyltransferase and pain

Oleg Kambur & Pekka T. Männistö

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