The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 2 offers 56 high level articles devoted mainly to Formation of Axons and Dendrites, Migration, Synaptogenesis, Developmental Sequences in the Maturation of Intrinsic and Synapse Driven Patterns.
- Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop
- Features leading experts in various subfields as Section Editors and article Authors
- All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship
- Volume 2 sections include coverage of mechanisms which regulate: the formation of axons and dendrites, cell migration, synapse formation and maintenance during development, and neural activity, from cell-intrinsic maturation to early correlated patterns of activity.
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About the Author
Dr. Rakic is currently at the Yale School of Medicine, Department of Neuroscience, where his main research interest is in the development and evolution of the human brain. After obtaining his MD from the University of Belgrade School of Medicine, his research career began in 1962 with a Fulbright Fellowship at Harvard University after which he obtained his graduate degrees in Developmental Biology and Genetics. He held a faculty position at Harvard Medical School for 8 years prior to moving to Yale University, where he founded and served as Chair of the Department of Neurobiology for 37 years, and also founder and director of the Kavli Institute for Neuroscience. In 2015, he returned to work full-time on his research projects, funded by US Public Health Services and various private foundations.
He is well known for his studies of the development and evolution of the brain, in particular his discovery of basic cellular and molecular mechanisms of proliferation and migration of neurons in the cerebral cortex. He was president of the Society for Neuroscience and popularized this field with numerous lectures given in over 35 counties. In 2008, Rakic shared the inaugural Kavli Prize in Neuroscience with Thomas Jessell and Stan Grillner. He is currently the Dorys McConell Duberg Professor of Neuroscience and serves on Advisory Boards and Scientific Councils of a number of Institutions and Research Foundations.
Table of Contents
I: Formation of Axons and Dendrites Chapter 1 – Development of Neuronal Polarity In Vivo - F. Polleux Chapter 2 – Role of the Cytoskeleton and Membrane Trafficking in Axon–Dendrite Morphogenesis - K.C. Flynn, M. Stiess, F. Bradke Chapter 3 - Axon Growth and Branching – L. Ma, D.A. Gibson Chapter 4 - Axon Guidance: Semaphorin/Neuropilin/Plexin Signaling – J. Falk, V. Castellani Chapter 5 - Roles of Eph–Ephrin Signaling in Axon Guidance –A.D. Chisholm, D.A. Feldheim Chapter 6 - Axon Guidance: Slit–Robo Signaling – F. Beaubien, J.E.A. Prince, J.-F. Cloutier Chapter 7 - Nonconventional Axon Guidance Cues – L. Izzi, F. Charron Chapter 8 - Axon Regeneration –T.L. Dickendesher, Y. Duan, R.J. Giger Chapter 9 - Axon Maintenance and Degeneration – F. Wang, Z. He Chapter 10 - Dendrite Development: Invertebrates – W.B. Grueber Chapter 11 - Dendritic Development: Vertebrates – C. Lohmann
II: Migration Chapter 12 - Cell Polarity and Initiation of Migration Chapter 13 - Leading Process Dynamics During Neuronal Migration – M. Valdeolmillos, F. Moya Chapter 14 – Nucleokinesis – O. Reiner, G. Gerlitz Chapter 15 - Migration in the Cerebellum – Y. Komuro, T. Kumada, N. Ohno, K.D. Foote, H. Komuro Chapter 16 - Radial Migration in the Developing Cerebral Cortex – S.C. Noctor, C.L. Cunningham, A.R. Kriegstein Chapter 17 - Radial Migration of Neurons in the Cerebral Cortex – A. Stanco, E.S. Anton Chapter 18 - Migration in the Hippocampus – G. Li, S.J. Pleasure Chapter 19 - Hindbrain Tangential Migration – C. Sotelo, A. Chedotal Chapter 20 - Tangential Migration: The Forebrain – T.J. Petros, S.A. Anderson Chapter 21 - Transcriptional Regulation of Tangential Neuronal Migration in the Vertebrate Hindbrain – T. Di Meglio, F.M. Rijli Chapter 22 - Postnatal Neurogenesis of the Forebrain - R. Belvindrah, P.-M. Lledo Chapter 23 - Migration of Myelin-Forming Cells in the CNS – F. de Castro, B. Zalc Chapter 24 - Neuronal Migration and Brain Patterning – A. Griveau, U. Borello, A. Pierani Chapter 25 - Neuronal Migration of Guidepost Cells – F. Bielle, S. Garel Chapter 26 - Neuronal Migration Disorders – J.J. LoTurco, A.B. Booker
III: Synaptogenesis Chapter 27 - Molecular Composition of Developing Glutamatergic Synapses – S.L. Barrow, A.K. McAllister Chapter 28 - In Vivo Imaging of Synaptogenesis – M. Munz, E.S. Ruthazer Chapter 29 - Genetic Analysis of Synaptogenesis – C.S. Lu, D. Van Vactor Chapter 30 - Activity-Regulated Genes and Synaptic Plasticity – J.H. Leslie, E. Nedivi Chapter 31 - New Imaging Tools to Study Synaptogenesis – S.J. Le Marchand, M.B. Dalva Chapter 32 - Wnt Signaling – P.C. Salinas Chapter 33 - Neurotrophins and Synaptogenesis, 39-658, F. Jeanneteau, M.V. Chao Chapter 34 - Ephrins and Eph Receptors – Synaptogenesis and Synaptic Function – A. Filosa, R. lein Chapter 35 - Neuroligins and Neurexins – D. Schreiner, P. Scheiffele Chapter 36 - Circuit Assembly in the Developing Vertebrate Retina – T. Yoshimatsu, S.C. Suzuki, R.O.L. Wong Chapter 37 - Synaptogenesis in the Adult CNS – Neocortical Plasticity – R. Eavri, E. Nedivi Chapter 38 - Synaptogenesis in the Adult CNS – Hippocampus – C. Zhao, N. Toni, F.H. Gage Chapter 39 - Synaptogenesis in the Adult CNS–Olfactory System – A. Mizrahi Chapter 40 - Synaptogenesis and Recovery from Cortical Trauma – R.J. Nudo, D. McNeal
IV: Developmental Sequences in the Maturation of Intrinsic and Synapse Driven Patterns; Chapter 41 - GABA: A Multifacet Device that Exerts a Crucial Role in Brain Development – Y. Ben-Ari Chapter 42 - Lessons from Zebrafish: Ion Channels Guide Neuronal Development –T.C. Martin, A.B. Ribera Chapter 43 - Regulation of AMPA-Type Glutamate Receptor Trafficking – Boekhoorn, C.C. Hoogenraad Chapter 44 - Pre- and Postsynaptic Assembly and Maturation: Principal Mechanisms and Coordination – S.J. Sigrist, C. Wichmann Chapter 45 - Cajal–Retzius and Subplate Cells: Transient Cortical Neurons and Circuits – H.J. Luhmann Chapter 46 - Chloride Homeodynamics Underlying Pathogenic Modal Shifts of GABA Actions – A. Fukuda Chapter 47 - GABAergic Signaling at Newborn Mossy Fiber–CA3 Synapses: Short- and Long-Term Activity-Dependent Plasticity Processes – E. Cherubini Chapter 48 - BDNF and the Plasticity of Brain Networks During Maturation – J.-L. Gaiarsa Chapter 49 - Retinal Waves: Underlying Cellular Mechanisms and Theoretical Considerations – E. Sernagor, M.H. Hennig Chapter 50 - Multimodal GABAA Receptor Functions on Cell Development – A. Fukuda, Y. Nakanishi, T. umada, T. Furukawa Chapter 51 - Retinal Waves and their Role in Visual System Development – M.B. Feller, D. erschensteiner Chapter 52 - The Maturation of Firing Properties of Forebrain GABAergic Interneurons – B.W. Okaty, S.B. Nelson Chapter 53 - Multiple Roles of CC2 in the Developing Brain – P. Uvarov, O. Llano, A. Ludwig, M.S. Airaksinen, C. Rivera Chapter 54 - NKCC1 and Brain Maturation – C.K. Pfeffer, C.A. Hübner Chapter 55 - Maturation of Inhibitory Synaptic Transmission in the Spinal Cord: Role of the Brain Stem and Contribution to the Development of Motor Patterns – L. Vinay Chapter 56 - Calcium Signals Regulate Neurotransmitter Phenotype – M. Demarque, N.C. Spitzer