As a man in a wheelchair crosses a speeding van's path, the driver loses control, rolling the van. When the driver wakes up in the hospital to find his wife and daughter dead, he embarks on a horrific course of vengeance to punish those responsible for his loss .
For the past seven years, Bill Colón has fought to accept his diagnosis of multiple sclerosis, a disease he calls The Bastard. Forced to use a wheelchair on occasion, he attends a mobility disabilities support group and is shocked to discover that its members are falling prey to a crazed serial killer-a man who targets men in wheelchairs. When Bill's brother-in-law, a homicide detective named Luis Ortiz, is assigned to the case, Bill feels compelled to become involved with the investigation.
One by one, unwitting men in wheelchairs are murdered. Although Bill doesn't want to be categorized as a man who fits the killer's profile, he soon realizes that he too is a target. Bill helps Luis pursue leads as much as his crippling disease will allow, but he has his limitations. Will Luis capture the serial killer before Bill ends up as the next victim?