| Julia Roberts | Charlotte the Spider |
| Steve Buscemi | Templeton the Rat |
| John Cleese | Samuel the Sheep |
| Oprah Winfrey | Gussy the Goose |
| Cedric the Entertainer | Golly the Goose |
| Kathy Bates | Bitsy the Cow |
| Reba McEntire | Betsy the Cow |
| Robert Redford | Ike the Horse |
| Thomas Haden Church | Brooks the Crow |
| André Benjamin | Elwyn the Crow |
| Dominic Scott Kay | Wilbur |
| Sam Shepard | Narrator |
| Abraham Benrubi | Uncle the Pig |
| Dakota Fanning | Fern |
| Kevin Anderson | Mr. Arable |
| Essie Davis | Mrs. Arable |
| Louis Corbett | Avery |
| Julian O'Donnell | Henry Fussy |
| Robyn Arthur | Teacher |
| Siobhan Fallon-Hogan | Mrs. Zuckerman |
| Gary Basaraba | Homer Zuckerman |
| Nate Mooney | Lurvy |
| Nicholas Bell | Minister |
| Beau Bridges | Dr. Dorian |
| Teague Rook | Well Dressed Man |
| Julia Zemiro | Bystander |
| Denise Kirby | New Teacher |
| Robert Plazek | Ball Thrower |
| Joseph Lotesto | Young Boy |
| Michael Roland | Mayor |
| Don Bridges | Announcer |
| Ian Watkin | Fair Official |
| Joel McCrary | Sheep Group |
| Brian Stepanek | Sheep Group |
| Fred Tatasciore | Sheep Group |
| Bradley White | Sheep Group |
| Maia Kirkpatrick | Joy the Baby Spider |
| Jennessa Rose | Aranea the Baby Spider |
| Briana Hodge | Nellie the Baby Spider |
| Jane Sibbett | Actor |
| Pete Anthony | Conductor |
| Sarah McLachlan | Singer |
Technical Credits
