| Ralph Macchio | Eugene Martone |
| Joe Seneca | Willie Brown |
| Jami Gertz | Frances |
| Joe Morton | Scratch's assistant |
| Robert Judd | Scratch |
| Steve Vai | Jack Butler |
| Dennis Lipscomb | Lloyd |
| Harry Carey | Bartender |
| John Hancock | Sheriff Tilford |
| Allan Arbus | Dr. Santis |
| Gretchen Palmer | Beautiful Girl/Dancer |
| Tim Russ | Robert Johnson |
| Akosua Busia | Woman at boardinghouse |
| Diana Bellamy | Hospital Supervisor |
| Gloria Delaney | Jookhouse Woman #1 |
| Tex Donaldson | John McGraw |
| Terry L. Evans | Keyboard |
| Al Fann | Pawnbroker |
| Winifred Freedman | Actor |
| Frank Frost | Harmonicist/Vocalist |
| Alan Lee Graf | Alvin |
| Deborra Hampton | Jookhouse Woman |
| Le Van Hawkins | Jookhouse Man |
| Karen Huie | Actor |
| Guy Killum | Willie at 17 |
| Debra Laws | Actor |
| Robert Miranda | Actor |
| Leslie Morris | Bus Station Clerk |
| Agnes Narciso | Miss Narciso |
| Jo Marie Payton-France | Jookhouse Woman |
| Natasha Peacock | Young Girl at Crossroads |
| John Price | Drum |
| Johnny M. Reyes | Orderly |
| Diane Robin | Nurse |
| Angela Louise Robinson | Jookhouse Woman |
| Jason Ross | Jookhouse Man |
| J.W. Smith | Man at Auto Wrecking Yard |
| Otis Taylor | Lead Guitar |
| Wally Taylor | O.Z. |
| Robin Townsend | Actor |
| Royce Wallace | Hotel Proprietress |
| Edward Walsh | Harley Terhune |
| Richard Shubby Holmes | Bass Guitar |
Technical Credits
| Walter Hill | Director |
| John Bailey | Cinematographer |
| Thomas Baum | Screenwriter |
| Mark Carliner | Producer |
| Lawrence James Cavanaugh | Special Effects |
| Jack T. Collis | Production Designer |
| Ry Cooder | Score Composer |
| Freeman Davies | Editor |
| John Fusco | Screenwriter |
| Michael Germain | Makeup |
| Albert Heschong | Art Director |
| Dan Moore | Costumes/Costume Designer |
| Nancy Patton | Set Decoration/Design |
| Barbara Siebert-Boticoff | Costumes/Costume Designer |
| James Tocci | Set Decoration/Design |
| Tim Zinnemann | Producer |
