Filmed between the original Thin Man and the first of its sequels, Evelyn Prentice re-teamed William Powell and Myrna Loy as another husband-and-wife team knee deep in a murder mystery. In this one, Powell is John Prentice, a prominent lawyer with an eye for women other than his own wife. His latest interest is Nancy Harrison (Rosalind Russell, in her film debut), a client accused of manslaughter, whom Prentice successfully defended. Loy plays John's wife, Evelyn, who loves him but is hurt by his inattention and the loneliness that ensues. This leads her to engage in a flirtation of her own, with a charming writer (Harvey Stephens). The writer, however, is interested in Evelyn only for what he can get out of her and threatens to blackmail her. In a panic, she shoots him and runs away, discovering later that he has been found dead and that another woman, Judith Wilson, has been accused of his murder. Hoping that his expert legal skills will the innocent woman her acquittal, Evelyn convinces her husband to take on Wilson's defense. As the film progresses, Evelyn feels increasingly pressured to admit that she is responsible for the man's death.