House of Strangers is the first of three film versions of Jerome Weidman's I'll Never Go Home Any More, each of which was scripted by Philip Yordan. Edward G. Robinson plays a Giannini-like Italian-American banker, Gino Monetti, who runs roughshod over his four grown sons. The ruthless Gino engages in several illegal activities to build up his business, and is arrested as a result. Though the sons have always been fully aware of their father's questionable business practices, they refuse to help him stay out of prison; led by oldest son Joe (Luther Adler), three of the sons take over the business and kick their father out. Only son Max (Richard Conte) remains loyal to his father, whereupon his three brothers conspire to have Max thrown into prison as well. Max promises the dying Gino that he'll exact vengeance on the treacherous sons; but when he is released, Max hasn't the stomach for revenge, not even after one of his brothers (Efrem Zimbalist Jr.) tries to kill him. Max leaves his brothers to stew in their own juices, and heads to California for a new life with his fiancée, Irene Bennett (Susan Hayward). Subsequent film versions of the Jerome Weidman novel included Broken Lance (1954) and The Big Circus (1961).