| Ray Romano | Manny |
| John Leguizamo | Sid |
| Denis Leary | Diego |
| Queen Latifah | Ellie |
| Seann William Scott | Crash |
| Josh Peck | Eddie |
| Jennifer Lopez | Shira |
| Jeremy Renner | Gutt |
| Wanda Sykes | Granny |
| Keke Palmer | Peaches |
| Aziz Ansari | Squint |
| Drake | Ethan |
| Heather Morris | Katie |
| Joy Behar | Eunice |
| Nicki Minaj | Steffie |
| Josh Gad | Louis |
| Alan Tudyk | Milton,Hunky Siren |
| Nick Frost | Flynn |
| Kunal Nayyar | Gupta |
| Alain Chabat | Silas |
| Christopher J. Campbell | Creature Siren,Various |
| Ester Dean | Female Siren |
| Peter Dinklage | Captain Gutt |
| Karen Disher | Scratte |
| Jason Fricchione | Dumb Mammoth,Various |
| Ben Gleib | Marshall |
| George Jacobs | Beaver |
| James Palumbo | Panicked Start |
| Simon Pegg | Buck |
| Alexandra Romano | Meghan |
| Matthew Simmons | Teen Elk |
| Eddie "Piolin" Sotelo | Uncle Fungus |
| Patrick Stewart | Ariscratle |
| Meghan Thurmeier | Baby Bird |
| Chris Wedge | Scrat |
| Rebel Wilson | Raz |
Technical Credits
| Steve Martino | Director |
| Michael Thurmeier | Director |
| Michael Berg | Original Story,Screenwriter |
| Scott Carroll | Animator |
| John C. Donkin | Producer |
| Nash Dunnigan | Art Director |
| Renato Falcao | Cinematographer |
| Lori Forte | Original Story,Producer |
| Jason Fuchs | Screenwriter |
| Andrew Hickson | Set Decoration/Design |
| Christian Kaplan | Casting |
| Chip Lotierzo | Animator |
| Matthew J. Munn | Animator |
| Anthony Nisi | Production Manager |
| James Palumbo | Editor |
| Tony Pitone | Asst. Director |
| John Powell | Score Composer |
| Amila Puhala | Animator |
| Patrik Puhala | Animator |
| Derek Rozmes | Animator |
| Jason Sadler | Set Decoration/Design |
| Carlos Saldanha | Executive Producer |
| David Ian Salter | Editor |
| David R. Sloss | Animator |
| Jackie Tarascio | Animator |
| Randy Thom | Sound/Sound Designer |
| Chris Wedge | Executive Producer |
