| Louis C.K. | Max |
| Kevin Hart | Snowball |
| Matthew McConaughey | Buster Moon |
| Sandra Bullock | Scarlett Overkill |
| Steve Carell | Gru,Gru/Dru |
| Eric Stonestreet | Duke |
| Jason Segel | Vector |
| Jon Hamm | Herb Overkill |
| Kristen Wiig | Lucy,Miss Hattie |
| Reese Witherspoon | Rosita |
| Benjamin Bratt | Eduardo/El Macho |
| Ellie Kemper | Katie |
| Michael Keaton | Walter Nelson |
| Russell Brand | Dr. Nefario |
| Seth MacFarlane | Mike |
| Trey Parker | Balthazar Bratt |
| Allison Janney | Madge Nelson |
| Julie Andrews | Gru's Mom |
| Lake Bell | Chloe |
| Miranda Cosgrove | Margo |
| Scarlett Johansson | Ash |
| Bobby Moynihan | Mel |
| Dana Gaier | Edith |
| John C. Reilly | Eddie |
| Will Arnett | Mr. Perkins |
| Jenny Slate | Gidget |
| Ken Jeong | Floyd |
| Steve Coogan | Silas |
Technical Credits
| Chris Renaud | Director |
| Garth Jennings | Director |
| Kyle Balda | Director |
| Pierre Coffin | Director |
| Christophe Lourdelet | Director |
