By Monogram standards, the cast of Isle of Missing Men was Academy Award calibre. John Howard and Gilbert Roland head a group of prisoners who try to escape from an island prison colony. Leading lady Helen Gilbert is willing to wait for her beloved Howard, but looks askance when he participates in the breakout. As was customary in such films, several of the more contentious prisoners are redeemed by sacrificing their lives for the sake of others. Alan Mobray, Bradley Page and George Chandler co-star in this adaptation of Gina Kaus and Ladislas Fodor's White Lady, while the direction is in the hands of German pioneer filmmaker Richard Oswald.