| Josh Brolin | Jonah Hex |
| John Malkovich | Quentin Turnbull |
| Megan Fox | Lilah |
| Michael Fassbender | Burke |
| Will Arnett | Lieutenant Grass |
| John Gallagher | Lieutenant Evan |
| Tom Wopat | Colonel Slocum |
| Jeffrey Dean Morgan | Jeb Turnbull |
| Wes Bentley | Adelman Lusk |
| Aidan Quinn | President Grant |
| Luke James Fleischmann | Travis |
| Rio Hackford | Grayden Nash |
| David Jensen | Turnbull's Henchman |
| Billy Blair | Turnbull's Gang - Billy |
| Sean Boyd | Turnbull's Gang - Preacher |
| John McConnell | Stunk Crick Sheriff |
| Jackson Townsend | Stunk Crick Mayor |
| T.J. Toups | Stunk Crick Deputy |
| Ned Coleman | Stunk Crick Deputy |
| Jack Wirt | Stunk Crick Deputy |
| Ty Holland | Dumbass Outlaw |
| J.D. Evermore | Union Officer on Train |
| Scott Staggers | Union Letter Writer |
| Jimmy Hayward | Train Wood Tender |
| Michael Arnona | Train Engineer |
| Noel Murano | Surviving Soldier |
| Preston Acuff | Union Officer at Fed Reserve |
| Jonathan Bell | Roughneck at Tent |
| Vincent Riverside | Roughneck at Tent |
| Stephen Chen | Old Chinese Guy |
| Joe Billingiere | Old Cherokee |
| Bill Martin Williams | Union Commanding Officer |
| Milos Milicevic | Bully Turnbull Guard |
| Eric Woods | Turnbull's Lookout |
| Maureen Brennan | Mother on Train |
| John Kennon Pepper | Boy on Train |
| L.W. Gray Hawk Perkins | Medicine Man |
| Seth Gabel | Advisor |
| Bruce "Sunpie" Barnes | Singer |
| Andy Ryan | Barber |
| Darin Heames | Bartender |
| Mitchell Amundsen | Customer |
| Matt Lasky | Dead Turnbull Guard |
| Rance Howard | Telegrapher |
| Antal Kalik | Huge Bar Patron |
| Michael Papajohn | Saber Guard |
| Tait Fletcher | Nasty Gunner |
| Paul Zies | Henchman #1 |
| Brian Elerding | Lookout |
| Lance Reddick | Smith |
| Jake Radaker | Boy |
| Michael Shannon | Doc Cross Williams |
| Julia Jones | Cassie |
Technical Credits
| Jimmy Hayward | Director |
| Kimberly Amacker | Makeup |
| Mitchell Amundsen | Cinematographer |
| Marco Beltrami | Score Composer |
| Kent Beyda | Editor |
| William Farmer | Original Story |
| William Fay | Executive Producer |
| Akiva Goldsman | Producer |
| John Goldstone | Executive Producer |
| Josh Hakian | Special Effects Supervisor |
| Jason Hamer | Makeup |
| Dan Hanley | Editor |
| Ryan Heck | Set Decoration/Design |
| Jon Jashni | Executive Producer |
| Daniel R. Jennings | Set Decoration/Design |
| Johnny Jos | Art Director |
| Rolf Keppler | Makeup |
| Andrew Lazar | Producer |
| Matt LeBlanc | Executive Producer |
| Joshua Levinson | Associate Producer |
| Tom Lewis | Editor |
| Rose Librizzi-Davis | Makeup |
| Margot E. Lulick | Co-producer |
| Jonah Markowitz | Art Director |
| Mastodon | Score Composer |
| Ravi Mehta | Executive Producer |
| Tom Meyer | Production Designer |
| Richard Middleton | Co-producer |
| Milos Milicevic | Asst. Director |
| Mark Neveldine | Original Story,Screenwriter |
| Billy O'Drobinak | Camera Operator |
| Brian Taylor | Original Story,Screenwriter |
| Bernie Telsey | Casting |
| Tinsley Studio | Makeup Special Effects |
| Thomas Tull | Executive Producer |
| Fernando Villena | Editor |
| Randy D. Wilkins | Set Decoration/Design |
| Michael Wilkinson | Costumes/Costume Designer |
| Jane Wuu | Set Decoration/Design |
| Hiroshi Yada | Makeup |
| Miri Yoon | Co-producer |
