| Anthony Hopkins | Coleman Silk,Bob Glass |
| Cate Blanchett | Philippa |
| Donald Sutherland | Frank |
| Isabella Rossellini | Maria |
| Jack Nicholson | Freddy Gale |
| Robin Williams | Gabriel Noone |
| Amy Irving | Karen |
| David Morse | John Booth |
| Giovanni Ribisi | Filippo |
| Nicole Kidman | Faunia Farley |
| Toni Collette | Donna Logand |
| Anjelica Huston | Mary |
| Bobby Cannavale | Jess |
| Campbell Scott | Leonard Markham |
| Ed Harris | Lester Farley |
| Remo Girone | His Father |
| Rider Strong | Pete |
| Christopher McDonald | Dan |
| Gary Sinise | Nathan Zuckerman |
| Joe Morton | Ashe |
| Robin Wright | Jojo |
| Ronald Nitschke | Otto |
| Stefania Rocca | Regina |
| Graham Greene | Calhoun |
| Hart Bochner | Russell |
| Matthis Sbargia | Major Pini |
| Piper Laurie | Helen Booth |
| Sandra Oh | Anna |
| Wentworth Miller | Coleman Silk as a young man |
| Rory Culkin | Pete Logand |
Technical Credits
| John Schlesinger | Director |
| Jonathan Heap | Director |
| Patrick Stettner | Director |
| Robert Benton | Director |
| Sean Penn | Director |
| Tom Tykwer | Director |