Four men trying to regain the excitement they knew in their youth are also having to deal with the decisions and responsibilities of adulthood in this comedy-drama. Kramer (Robert Curtis-Brown), Stan (Shea Farrell), Skinner (John Putch), and Mikey (Dwier Brown) are four longtime friends, who, in their younger days, worked as river rafting guides. Spending their days on the water and their nights partying under the moonlight, they seemed to be living the sort of life many people dream of, until another guide died in an accident on the river rapids. A dozen years later, the four friends have gotten back together to ride the river one more time, but life is hardly the same for any of them. Skinner still feels he was somehow responsible for the death of the fifth guide, and these days he scrapes together a living as a bicycle repairman. Kramer is happily married, but he and his wife and struggling with the news that their young daughter has a crippling and potentially fatal illness. Stan recently broke up with his wife and is unable to relate to his teenage son. And Mikey has done well in his career as a lawyer, but hasn't been as lucky in love, and he isn't sure if he's ready to propose marriage to his longtime girlfriend. Same River Twice was the first feature film for director Scott Featherstone.