| John Wayne | Capt. Kirby York,Ethan Edwards,Sheriff John T. Chance,Wil Anderson |
| Dean Martin | Dude |
| Henry Fonda | Lt. Col. Owen Thursday |
| Jeffrey Hunter | Martin Pawley |
| Roscoe Lee Browne | Jebediah Nightlinger |
| Bruce Dern | Asa Watts ("Long Hair") |
| Rick Nelson | Colorado Ryan |
| Vera Miles | Laurie Jorgensen |
| Ward Bond | Sgt. Major O'Rourke,Capt. Reverend Clayton |
| Angie Dickinson | Feathers |
| Colleen Dewhurst | Kate |
| Shirley Temple | Philadelphia Thursday |
| John Agar | Lt. Michael "Mickey" O'Rourke |
| Natalie Wood | Debbie Edwards, older |
| Slim Pickens | Anse |
| Walter Brennan | Stumpy |
| Pedro Armendariz | Sgt. Beaufort |
| Sam O'Brien | Jimmy Phillips |
| Dick Foran | Sgt. Quincannon |
| Mike Pyeatt | Homer Weems |
Technical Credits
| Howard Hawks | Director |
| John Ford | Director |
| Mark Rydell | Director |