| Melissa McCarthy | Tammy |
| Susan Sarandon | Pearl |
| Kathy Bates | Lenore |
| Mark Duplass | Bobby |
| Dan Aykroyd | Don |
| Sandra Oh | Susanne |
| Gary Cole | Earl |
| Toni Collette | Missi |
| Allison Janney | Deb |
| Nat Faxon | Greg |
| Ben Falcone | Keith Morgan |
| Sarah Baker | Becky |
| Rich Williams | Larry |
| Steve Little | Jet Ski Rental Guy |
| Dakota Lee | Kathleen |
| Mark L. Young | Jesse |
| Mia Rose Frampton | Karen |
| Steve Mallory | Cashier |
| Big Al Hall | Possum Creek Bluegrass Band |
| Jones Smith | Possum Creek Bluegrass Band |
| Joe Baxter | Possum Creek Bluegrass Band |
| Benjamin Chontos | Possum Creek Bluegrass Band |
| Sean Gould | Possum Creek Bluesgrass Band |
| Oscar Gale | Javier |
| Justin Smith | Paramedic |
| Willie Hill | Prison Guard |
| Zach Hanner | Men at Blue Post Bar-B-Que |
| Jason Vail | Men at Blue Post Bar-B-Que |
| Leon Lamar | Old Man with Walker |
| Larry Dorf | Officer Mannis |
| Ricky Muse | Officer Curtis |
| Barbara Weetman | Officer Carty |
| William Flaman | La Grange Bail Cop |
| Rey Hernandez | Cop at Lakehouse |
| Penn Holderness | News Anchor |
| Michelle Li | News Reporter |
| Raven Angeline Whisnant | Charlotte |
| Damon Jones | Jerry Miller |
| Sandy McCarthy | Two Old Ladies Leaving a Bar |
| Margo Passas | Two Old Ladies Leaving a Bar |
Technical Credits
| Ben Falcone | Director,Executive Producer,Screenwriter |
| Russ T. Alsobrook | Choreography,Cinematographer |
| Michael Andrews | Score Composer |
| Vince Ball | Special Effects |
| David Beavis | Special Effects Supervisor |
| Richard Brener | Executive Producer |
| Wendy Chuck | Costumes/Costume Designer |
| Rob Cowan | Executive Producer |
| Billy Daniel | Special Effects |
| Michael Disco | Executive Producer |
| Toby Emmerich | Executive Producer |
| Will Ferrell | Producer |
| Richard Fojo | Art Director |
| Walter Gasparovic | Asst. Director |
| Chris Henchy | Executive Producer |
| James Jenkins | Special Effects |
| Allison Jones | Casting |
| Melissa McCarthy | Producer,Screenwriter |
| Adam McKay | Producer |
| Tim McKinney | Special Effects |
| Kevin J. Messick | Executive Producer |
| Manish Raval | Musical Direction/Supervision |
| Michael Rayle | Sound Mixer |
| Rhythm & Hues Studios | Animator |
| Jefferson Sage | Production Designer |
| Mike Sale | Editor |
| Derek T. Spears | Animator |
| Tom Wolfe | Musical Direction/Supervision |
