| Jeff Bridges | Kevin Flynn/Clu |
| Garrett Hedlund | Sam Flynn |
| Olivia Wilde | Quorra |
| Bruce Boxleitner | Alan Bradley/Tron |
| James Frain | Jarvis |
| Beau Garrett | Gem |
| Michael Sheen | Castor/Zuse |
| Anis Cheurfa | Rinzler |
| Serinda Swan | Siren #2 |
| Yaya DaCosta | Siren #3 |
| Elizabeth Mathis | Siren #4 |
| Yurij Kis | Half Faced Man |
| Conrad Coates | Bartik |
| Daft Punk | Masked DJs |
| Ronald Selmour | Chattering Homeless Man |
| Dan Joffre | Key Security Guard #1 - Ernie |
| Darren Dolynski | Young Man on Recognizer |
| Kofi Yiadom | Disc Opponent #2,Black Guard |
| Steven Lisberger | Shaddix |
| Donnelly Rhodes | Grandpa Flynn |
| Belinda Montgomery | Grandma Flynn |
| Owen Best | 7 Year Old Sam Flynn |
| Matt Ward | Iso Boy |
| Zoe Fryklund | Iso Girl |
| Dean Redman | Light Jet Sunny |
| Mi-Jung Lee | Debra Chung |
| Christopher Logan | Nervous Program |
| Sheldon Yamkovy | Destitute Program |
| Dale Wolfe | Irv Culpepper |
| Joanne Wilson | Reporter #1 |
| Catherine Lough Haggquist | Reporter #2 |
| Thomas Bradshaw | Security Guard #2 |
| Shafin Karim | East Indian Taxi Driver |
| Rob Daly | Lead Sentry |
| Mike Ching | Blue Gaming Program |
| Michael Teigen | Green Gaming Program |
| Brent Stait | Purple Gaming Program |
| Shaw Madson | Reporter #3 |
| Amy Esterle | Young Mrs. Flynn |
| Cody Laudan | End of the Line Club Bouncer |
| Jeffrey Nordling | Richard Mackey |
| Christine Adams | Claire Atkinson |
| Kate Gajdosik | News Anchor |
| Jack McGee | Police Photographer |
| Dawn Mander | Crying Program |
| Edie Mirman | Computer |
| Allen Jo | Black Guard,Disc Opponent #1 |
| Aaron Toney | Black Guard |
| Kim Do Nguyen | Black Guard |
| Patrick Sabongui | Gaming Program 1-S |
| Will Erichson | Gaming Program 2-S |
Technical Credits
| Joseph Kosinski | Director |
| Sean Bailey | Producer |
| Thomas Bangalter | Score Composer |
| Jason Bentley | Musical Direction/Supervision |
| Steve Boeddeker | Sound/Sound Designer |
| Christopher Boyes | Sound/Sound Designer |
| Heike Brandstatter | Casting |
| Alex Burdett | Special Effects Supervisor |
| John Clothier | Camera Operator |
| Daft Punk | Score Composer |
| Guy-Manuel de Homem-Christo | Cinematographer |
| Digital Domain | Animator |
| Benjamin Edelberg | Set Decoration/Design |
| Sarah Halley Finn | Casting |
| Bruce Franklin | Associate Producer,Asst. Director |
| Steve Gaub | Co-producer |
| Darren Gilford | Production Designer |
| Justis Greene | Associate Producer |
| Sean Haworth | Art Director |
| James Haygood | Editor |
| Adam Horovitz | Original Story,Screenwriter |
| Luis G. Hoyos | Set Decoration/Design |
| Robert Andrew Johnson | Set Decoration/Design |
| Robert Johnson | Set Decoration/Design |
| Michelle Johnston | Choreography |
| Edward Kitsis | Original Story,Screenwriter |
| Brian Klugman | Original Story |
| Donald Kushner | Executive Producer |
| Steven Lisberger | Producer |
| Coreen Mayrs | Casting |
| Michael McGee | Sound Mixer |
| Claudio Miranda | Cinematographer |
| Thomas Nellen | Makeup |
| Jeffrey Silver | Producer |
| Trig Singer | Camera Operator |
| William Ladd Skinner | Art Director |
| Justin Springer | Co-producer |
| Lee Sternthal | Original Story |
| Bill Terezakis | Makeup Special Effects |
| Maureen Terezakis | Makeup Special Effects |
| Grant Van Der Slagt | Art Director |
| Pete Whyte | Asst. Director |
| Michael Wilkinson | Costumes/Costume Designer |
