Immunobiology of Transfer Factor

by Charles H. Kirkpatrick, Denis R. Burger, H. Sherwood Lawrence

Overview

Immunobiology of Transfer Factor compiles research papers presented at the Fourth International Transfer Factor Workshop, held at the Given Institute of Pathobiology in Aspen, Colorado, on October 3-6, 1982.

This book focuses on the immunologic effects of transfer factor, which are supported by in vitro and in vivo experiments that indicate immunologically specific interactions between transfer factor and antigens. The topics include the selective removal of transfer factor activity with antigen, antigen-specific suppressor factor in human leukocyte dialysates, and specific suppressor dialysates from mice. The kinetics of immune response and production of transfer factor in bovine, dialyzable leukocyte extracts in pulmonary diseases, and mechanisms of action of human transfer factor are also elaborated.

This compilation is suitable for microbiologists, immunologists, and specialists researching on transfer factor.

Product Details

ISBN-13:	9781483277684
Publisher:	Elsevier Science
Publication date:	06/28/2014
Sold by:	Barnes & Noble
Format:	NOOK Book
Pages:	462
File size:	8 MB

Table of Contents

Contributors


Preface


Acknowledgments


The Merrill W. Chase Prize in Cellular Immunology


Section I. The Nature of Transfer Factor


The Immunological Enigma of Transfer Factor


Human Transfer Factor: Specificity and Structural Models


Human Transfer Factor: Exogenous Labeling, Purification, and Role of Ribonucleic Acid Segment


Selective Removal of Transfer Factor Activity with Antigen


Antigen-Specific Inducer Factor in Human Leukocyte Dialysates: A Product of TH Cells which Binds to Anti-V Region and Anti-La Region Antibodies


Antigen-Specific Suppressor Factor in Human Leukocyte Dialysates: A Product of Ts Cells which Binds to Anti-V Region and Anti-La Region Antibodies


Isolation and Purification of Antigen-Specific Inducer and Suppressor Factors from Pooled Leukocyte Dialysates of Unselected Donors by Affinity Adsorption


Section II. Studies of Dialyzable Leukocyte Extracts in Animals


Dialyzable Leukocyte Extract Containing Transfer Factor—Its Future in Veterinary Medicine


Effect of Dialyzable Leucocyte Extract and Other Tissue Dialysates on Listeria Resistance


Osteosarcoma-Specific Dialyzable Extracts: Prophylaxis Post Surgery in an Animal Model of Human Osteosarcoma


Antigen-Specific Transfer Factor Induced in Mice by an Attenuated Virus from the Tick-Borne Encephalitis Complex: Biological, Histological, and Concentration Studies


Antigen-Specific Suppressor Factor in Human Leukocyte Dialysates Suppresses in Vivo Footpad Reactivity in Immunized BALB/c Mice


Specific Suppressor Dialysates from Mice


Kinetics of Immune Response and Production of Transer Factor in Bovine


Transfer of Cell-Mediated Immunity in Vitro to Human Lymphocytes Using Dialyzable Leukocyte Extracts from Immune Burros


Section III. Studies of Dialyzable Leukocyte Extracts in ManThe Use of Antigen Specific Transfer Factor in the Management of Infections with Herpes Viruses


Specific Bovine Transfer Factor for the Treatment of Herpes Infections


Oral Bovine Transfer Factor (OTF) Use in the Hyper-IgE Syndrome


Dialyzable Leukocyte Extracts in Pulmonary Diseases (Lung Cancer and Recurrent Bronchitis)


Clinical Use of Leukocyte Dialysate (Transfer Factor) in Osaka Area of Japan


Clinical Applications of the Leukocyte Migration Inhibition Assay—New Methods for Determining Transfer Factor Potency and for Predicting Clinical Response


The Effects of Immune and Nonimmune Dialyzable Leucocyte Extracts on KLH and HCH Reactivity in Unprimed Human Recipients: A Double Blind Study


Section IV. In Vitro Activities in Dialyzable Leukocyte Extracts


Mechanism(s) of Action of Human Transfer Factor: Insights Obtained from Studying "Antigen-Liberated Transfer Factor" Specific for Tuberculin


Dialyzable Leukocytes Extracts (D.L.E.) and Theophylline-Treated Lymphocytes


Dialyzable Leucocyte Extract Stimulates cAMP in Τγ Lymphocytes: Lack of Fc-Receptor Induction or NK-Cell Activation


Porcine Spleen Cell Dialysate Increases the Phagocytic Capacity and Decreases Prostaglandin Levels of Peritoneal Macrophages in Mouse


Initial Characterization of an Ampliative Nucleoside Isolated from Human Dialyzable Leukocyte Lysate


Immunochemical and Physical-Chemical Evidence for the Presence of Thymosin AlpharPeptide in Dialyzable Leukocyte Extracts


Thymosin α1-Like Material in Dialy sates of Leukocyte Extracts


Transfer Factor and Immune RNA


Closing Comments


Index