Laboratory Investigation of Endocrine Disorders

Laboratory Investigation of Endocrine Disorders

by Michael R. Wills, Bill Havard

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Overview

Laboratory Investigation of Endocrine Disorders, Second Edition serves as a basic guide to the available endocrine laboratory tests. This book discusses the developments in the understanding of the mechanisms involved in the pathogenesis of endocrine disorders.
Organized into 9 chapters, this edition begins with an overview of the control of thyroid hormone secretion. This text then explains the role of hypothalamus in the control of the activities of the functionally distinct anterior and posterior lobes of the pituitary gland. Other chapters consider the disorders of calcium homeostasis and their investigation with specific reference to hypocalcemia and hypercalcemia. This book discusses as well the adrenal cortical function. The final chapter deals with the normal steady-state regulation of calcium, which includes diet, physiological mechanisms, and hormones.
This book is a valuable resource for laboratory-based scientists, both the medical and the non-medical. Senior clinical students and medical practitioners will also find this book useful.

Product Details

ISBN-13: 9781483182605
Publisher: Elsevier Science
Publication date: 10/22/2013
Sold by: Barnes & Noble
Format: NOOK Book
Pages: 126
File size: 2 MB

Table of Contents

1. Thyroid Disorders


Physiology


Specimens and Normal Range Values


Total Serum Thyroxine (T4)


Total Serum Tri-Iodothyronine (T3)


Free Binding Capacity (FBC)


Free Thyroxine Index (FTI)


Thyrotrophin (TSH)


In Vivo Tests


99mTc Uptake


Thyroid Scan


Thyrotrophin-Releasing Hormone (TRH) Test


Other Tests


Thyroid Antibodies in Thyroiditis


Thyroid-Stimulating Antibodies (TSAB)


Cholesterol


Diagnostic Considerations


Hypothyroidism


Hyperthyroidism


Investigation of Thyroid Status in Patients after Treatment of Hyperthyroidism


Investigation of Thyroid Status in Patients after Treatment of Hypothyroidism


2. Hypothalamic-Anterior Pituitary Disorders


Physiology


Specimens and Normal Range Values


Growth Hormone


Follicle-Stimulating and Luteinizing Hormones


Prolactin


Adrenocorticotrophin


Dynamic Tests


LH-RH Test


Combined Test


Diagnostic Considerations


Hypopituitarism


Growth Hormone Excess


Galactorrhoea


Precocious Puberty


3. Hypothalamic-Pituitary-Adrenocortical Axis


Physiology


Specimens and Normal Range Values


Plasma Cortisol


Urine for Steroids


Normal Range Values


Dynamic Tests


Tetracosactrin


Dexamethasone Suppression Tests


Metyrapone Test


Diagnostic Considerations


Adrenocortical Hyperplasia (Cushing's Syndrome)


Adrenocortical Hypofunction


4. Hypothalamic-Posterior Pituitary Disorders


Physiology


Specimens and Normal Range Values


Diagnostic Considerations


Diabetes Insipidus


Inappropriate ADH Syndrome


5. Adrenal Cortical Disorders


Physiology


Specimens and Normal Range Values


Plasma Cortisol


Plasma Renin and Aldosterone


Plasma 17-α-Hydroxyprogesterone


Urine Pregnanetriol


Urine 11-Oxygénation Index


Diagnostic Considerations


Primary Adrenocortical Hypofunction (Addison's Disease)


Secondary Adrenocortical Hypofunction


Congenital Adrenal Hyperplasia


Primary Hyperaldosteronism (Conn's Syndrome)


Secondary Hyperaldosteronism


Hypoaldosteronism


6. Disorders of the Adrenal Medulla


Physiology


Specimens and Normal Range Values


Plasma


Urine


Diagnostic Considerations


Phaeochromocytoma


7. Ovarian Disorders


Physiology


Gametogenesis


Secretion of Oestrogens


Specimens and Normal Range Values


Oestradiol-17-ß


Progesterone


Pregnanediol


Urine Total Oestrogens in the Non-Pregnant


Urine Total Oestrogens in Pregnancy


Dynamic Tests


Clomiphene Stimulation Test


LH-RH Test


Human Menopausal Gonadotrophin Stimulation


Clinical Considerations


Amenorrhoea


Infertility


Hyperprolactinaemic Hypogonadism


Precocious Puberty


Hirsuties and Virilism


8. Testicular Disorders


Physiology


Specimens and Normal Range Values


Plasma LH and FSH


Plasma Testosterone


Urine 17-Oxosteroids


Dynamic Tests


Clomiphene Stimulation Test


HCG Stimulation Test


Diagnostic Considerations


Infertility


Hypogonadism


Precocious Puberty


9. Disorders of Calcium Homeostasis


Physiology


Specimens and Normal Range Values


Calcium (Total)


Calcium (Ionized)


Plasma Phosphorus


Phosphate Excretion Tests


Magnesium


Serum Proteins and Albumin


Alkaline Phosphatase


Parathyroid Hormone


25-Hydroxyvitamin D and 1,25 Dihydroxycholecalciferol


Calcitonin


Urine Calcium


Urine Hydroxyproline


Urine Cyclic AMP


Dynamic Tests


Cortisone Suppression Test


Diagnostic Considerations


Hypercalcaemia


Hypocalcaemia


Appendix Normal Reference Values and Factors for the Conversion of Conventional to Si Units

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