The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases.
An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis.
- Highlights the concept of the mosaic of autoimmune manifestations
- Includes new visions on unsuspected molecules
- Provides updated knowledge to physicians helping patients with autoimmune diseases
- Presents thorough, up-to-date information on specific diseases, along with clinical applications
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About the Author
Dr. Carlo Perricone, is a ECR in autoimmune diseases, Born in Rome on 19 April 1984. 'Surgeon Specialist in Rheumatology, has a Ph.D. in Immunological Sciences, hematology, and Rheumatics at Sapienza University of Rome. He received with honors the Master Degree in Medicine and Surgery in July 2007 at the University of Rome
Prof. Yehuda Shoenfeld is the founder and head of the Zabludowicz Center for Autoimmune Diseases, at the Sheba Medical Center which is affiliated to the Sackler Faculty of Medicine in Tel-Aviv University, in Israel. Dr. Shoenfeld is the Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases at the Tel-Aviv University.
His clinical and scientific works focus on autoimmune and rheumatic diseases, and he has published more than 1750 papers in journals such as New Eng J Med, Nature, Lancet, Proc Nat Acad Scie, J Clin Invest, J Immunol, Blood, FASEB, J Exp Med, Circulation, Cancer and others. His articles have had over 35,000 citations. He has written more than three hundred and fifty chapters in books, and has authored and edited 25 books, some of which became cornerstones in science and clinical practice, such as "The Mosaic of Autoimmunity", "Infections and Autoimmunity" and the textbook "Autoantibodies" and "Diagnostic criteria of autoimmune diseases", all of which were published by Elsevier and sold by the thousands.
He is on the editorial board of 43 journals in the field of rheumatology and autoimmunity and is the founder and the editor of the IMAJ (Israel Medical Association Journal) the representative journal of science and medicine in the English language in Israel, and also is the founder and Editor of the "Autoimmunity Reviews" (Elsevier) (Impact factor 7.9) and Co-Editor of "Journal of Autoimmunity" (Impact factor 8.1). He has organized over 20 international congresses in autoimmunity.
Prof. Shoenfeld received the EULAR prize in 2005, in Vienna, Austria: "The infectious etiology of anti-phospholipid syndrome". He has received a gold medal from the Slovak Society of Physicians for his contribution to Israel – Slovakia collaboration (March 2006), and is honorary member of the Hungarian Association of Rheumatology. In UC Davis, USA, Dr. Shoenfeld received the Nelson's Prize for Humanity and Science for 2008. In 2009 he was honored as Doctoris Honoris Causa, from Debrecen University (Hungary), and from 2009 he is honorary member of the Slovenian National Academy of Sciences. He has recently been awarded a Life Contribution Prize in Internal Medicine in Israel, 2012 as well as the ACR Master Award in 2013.
Prof. Shoenfeld has educated a long list of students (<25) being heads of departments and institutes.
Table of Contents
Introduction 1. The history of the mosaic of autoimmunity 2. The novel aspects on the mosaic of autoimmunity
Cellular and molecular mechanisms 3. B cells 4. B-reg 5. T cells 6. Th17 cells 7. NK cells 8. Dendritic cells 9. Complement 10. Autoantibodies 11. Anti-DSF70 12. Genetic 13. Epigenetic 14. Post-translational modifications 15. Cytokines and chemokines 16. Autophagy 17. Diagnostic: laboratory 18. Diagnostic: imaging
The classical factors associated with autoimmunity 19. Hormones 20. Microbiota 21. Infections: Viruses and bacteria
The novel environmental factors associated with autoimmunity 22. Geo-epidemiology 23. Seasonality 24. UV 25. Vitamin D 26. Vitamin D pregnancy and autoimmunity 27. Smell 28. Breast feeding 29. Vaccines 30. Silicone 31. Diet: spicy food and fatty acids 32. Diet: gluten 33. Psychological stress 34. Coffee 35. Obesity 36. Physical activity 37. Smoke 38. Cannabis 39. Bisphenol 40. Prolactin
Peculiar aspects 41. Cancer 42. Paraneoplastic syndromes
Classical autoimmune diseases 43. SLE 44. APS 45. CAPS 46. RA and inflammatory arthritides 47. PsA and Spondyloarthropathies 48. MS, MG and other neurological disorders 49. Systemic slcerosis 50. Sjogren 51. ASIA syndrome 52. Reproductive failure 53. Accelerated atherosclerosis 54. New autoimmune diseases
Treatment of autoimmune diseases 55. Neuroimmunology 56. Vasculitis 57. Personalized Medicine 58. Biologics and Biosimilars 59. Small molecules 60. Helminthes 61. Novel therapies and IVIg 62. Autoimmune and allergic disease 63. EBV Molecular Diagnosis 64. Statin and myositis 65. Autoimmunity and primary immunodeficiency