The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 1 offers 48 high level articles devoted mainly to patterning and cell type specification in the developing central and peripheral nervous systems.
- Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop
- Features leading experts in various subfields as Section Editors and article Authors
- All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship
- Volume 1 sections include coverage of mechanisms which: control regional specification, regulate proliferation of neuronal progenitors and control differentiation and survival of specific neuronal subtypes, and controlling development of non-neural cells
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About the Author
Dr. Rakic is currently at the Yale School of Medicine, Department of Neuroscience, where his main research interest is in the development and evolution of the human brain. After obtaining his MD from the University of Belgrade School of Medicine, his research career began in 1962 with a Fulbright Fellowship at Harvard University after which he obtained his graduate degrees in Developmental Biology and Genetics. He held a faculty position at Harvard Medical School for 8 years prior to moving to Yale University, where he founded and served as Chair of the Department of Neurobiology for 37 years, and also founder and director of the Kavli Institute for Neuroscience. In 2015, he returned to work full-time on his research projects, funded by US Public Health Services and various private foundations.
He is well known for his studies of the development and evolution of the brain, in particular his discovery of basic cellular and molecular mechanisms of proliferation and migration of neurons in the cerebral cortex. He was president of the Society for Neuroscience and popularized this field with numerous lectures given in over 35 counties. In 2008, Rakic shared the inaugural Kavli Prize in Neuroscience with Thomas Jessell and Stan Grillner. He is currently the Dorys McConell Duberg Professor of Neuroscience and serves on Advisory Boards and Scientific Councils of a number of Institutions and Research Foundations.
Table of Contents
I: Induction and Patterning of the CNS and PNS Chapter 1 – Telencephalon Patterning - S. Tole, J. Hébert Chapter 2 – Morphogens, Patterning Centers, and their Mechanisms of Action - E.A. Grove, E.S. Monuki Chapter 3 – Midbrain Patterning: Isthmus Organizer, Tectum Regionalization, and Polarity Formation - H. Nakamura Chapter 4 – Area Patterning of the Mammalian Cortex - D.D.M. O'Leary, A.M. Stocker, A. Zembrzycki Chapter 5 – The Formation and Maturation of Neuromuscular Junctions - C.R. Hayworth, R.J. Balice-Gordon Chapter 6 – Neural Induction of Embryonic Stem/Induced Pluripotent Stem Cells - K. Brennand, F. Gage Chapter 7 – Spinal Cord Patterning - W.D. Gifford, M. Hayashi, M. Sternfeld, J. Tsai, W.A. Alaynick, S.L. Pfaff Chapter 8 – Patterning of the Diencephalon - L. Puelles, S. Martinez Chapter 9 – Neural Induction Embryonic Stem Cells - C. Kintner, A. Hemmati-Brivanlou Chapter 10 – Plan of the Developing Vertebrate Nervous System: Relating Embryology to the Adult Nervous System (Prosomere Model, Overview of Brain Organization) - L. Puelles Chapter 11 – Cerebellar Patterning - J.K. Fahrion, Y. Komuro, N. Ohno, Y. Littner, C. Nelson, T. Kumada, B. Lamb, H. Komuro Chapter 12 – Hox Genes and Neural Patterning in Drosophila - P.A. Kuert, H. Reichert Chapter 13 – Induction and Patterning of Neural Crest and Ectodermal Placodes and their Derivatives - J. Begbie
II: Generation of Neuronal Diversity Chapter 14 – Cell Biology of Neuronal Progenitor Cells - S. Temple, Q. Shen Chapter 15 – Cell Cycle Regulation in Brain Construction - M. Crespo, M.E. Ross Chapter 16 – Regulation of Neuronal Survival by Neurotrophins in the Developing Peripheral Nervous System - A.M. Davies Chapter 17 – Notch and Neural Development - J.J. Breunig, B.R. Nelson Chapter 18 – bHLH Factors in Neurogenesis and Neuronal Subtype Specification - H.C. Lai, D.M. Meredith, J.E. Johnson Chapter 19 – Environmental Cues and Signaling Pathways that Regulate Neural Precursor Development - A. Gauthier-Fisher, F.D. Miller Chapter 20 - Specification of Neural Crest- and Placode-Derived Neurons - L. Sommer Chapter 21 – The Specification and Generation of Neurons in the Ventral Spinal Cord - M. Matise, K. Sharma Chapter 22 – Neurogenesis in the Cerebellum - V.V. Chizhikov, K.J. Millen Chapter 23 – The Generation of Midbrain Dopaminergic Neurons - S.R.W. Stott, S.-L. Ang Chapter 24 – Neurogenesis in the Basal Ganglia - J.L.R. Rubenstein, K. Campbell Chapter 25 – Specification of Cortical Projection Neurons: Transcriptional Mechanisms - J.L. MacDonald, R.M. Fame, E. Azim, S.J. Shnider, B.J. Molyneaux, P. Arlotta, J.D. Macklis Chapter 26 – The Generation of Cortical Interneurons - R. Batista-Brito, G. Fishell Chapter 27 – Specification of Retinal Cell Types - R.B. Hufnagel, N.L. Brown Chapter 28 – Neurogenesis in the Postnatal VZ-SVZ and the Origin of Interneuron Diversity - A. Alvarez-Buylla, F. Merkle, L. Fuentealba Chapter 29 – Neurogenesis in the Damaged Mammalian Brain - M. Nakafuku, A. Grande Chapter 30 – Neurogenesis in the Nematode Caenorhabditis elegans* - O. Hobert Chapter 31 – Development of the Drosophila Embryonic Ventral Nerve Cord: From Neuroectoderm to Unique Neurons and Glia - J. Benito-Sipos, M. Baumgardt, S. Thor Chapter 32 – Neurogenesis in Zebrafish - A. Alunni, M. Coolen, I. Foucher, L. Bally-Cuif
III: Development of Glia, Blood Vessels, Choroid Plexus, Immune Cells in the Nervous System Chapter 33 – ‘Glial’ Biology: Has it Come to the Beginning of the End? - D. Rowitch, A. Alvarez-Buylla Chapter 34 – Neural Stem Cells Among Glia - A. Alvarez-Buylla, A. Kriegstein Chapter 35 – Structure and Function of Myelinated Axons - S.A. Buffington, M.N. Rasband Chapter 36 – Mechanisms of Astrocyte Development - A.V. Molofsky, C. Hochstim, B. Deneen, D. Rowitch Chapter 37 – Specification of Macroglia by Transcription Factors: Oligodendrocytes - M. Wegner Chapter 38 – Specification of Macroglia by Transcription Factors: Schwann Cells - D. Meijer, J. Svaren Chapter 39 –Signaling Pathways that Regulate Glial Development and Early Migration – Oligodendrocytes - R.H. Miller Chapter 40 – Signaling Pathways that Regulate Glial Development and Early Migration – Schwann Cells - K.R. Jessen, R. Mirsky Chapter 41 – Microglia - A.E. Cardona, R.M. Ransohoff, K. Akassoglou Chapter 42 – Ependyma, Choroid - A. Meunier, K. Sawamoto, N. Spassky Chapter 43 – Meninges and Vasculature - J.A. Siegenthaler, S.J. Pleasure Chapter 44 – Neuron–Glial Interactions: Schwann Cells - M.H. Schwab, M.W. Sereda, K.-A. Nave Chapter 45 – Neuron–Glial Interactions: Neurotransmitter Signaling to Cells of the Oligodendrocyte Lineage - L.M. De Biase, D.E. Bergles Chapter 46 – Invertebrate Glia - T. Stork, M.R. Freeman Chapter 47 – Nonmammalian Model Systems: Zebrafish - B. Appel Chapter 48 – New Approaches in Glial Biology: Imaging Neuroglial Pathology In Vivo - I. Nikić, T. Misgeld, M. Kerschensteiner Index